The Catholic community in Anguilla started with just a handful of Catholics. The first recorded baptism took place in a home in 1948. In the early 1950's, when there were about a dozen Catholics, a small wooden church, called Holy Rosary, was built by Father Thomas Grace, on the border of the Wallblake Estate Property. He lived in a small two room house nearby. The church was damaged and house destroyed in the 1961 hurricane.

In 1959 Marie Lake , the sole heiress of the Wallblake Estate, donated the house and property to the Catholic Church. On Christmas of that year, mass was celebrated in the Wallblake House for the first time, to accommodate the number of Catholics that now had increased to 63.

Father Alphonse Roberge, C.S.S.R. arrived in 1963. It was during this time that the Great Room in the Wallblake House became too small for the Sunday congregation. A new church, designed and built by Father Joseph Stryckers, (a Belgium Redemptorist) was dedicated in 1966.

After 1971, there was a period of thirteen years without a resident priest; though a priest came once or twice a month from St. Kitts to offer mass. Upon the arrival of Father John Valentine, SVD in 1984, the Wallblake House, which in the interim had been rented out, was again used as a presbytery until 1998, when the decision was made to build a new presbytery. Since then (2003), the Wallblake House (built in 1786) has been restored and made available for heritage/historical tours, and the new presbytery was completed in the year 2000.

A church census taken in 1973, recorded 45 adult Catholics and 93 children. Subsequently that number dropped, in the absence of a resident pastor during a thirteen year period. The census of 1992 showed 213 Catholics; and the census of 2001 numbered the Catholic population at 654. The majority of Catholics in Anguilla have their roots in other islands. Currently there are 320 parishioners registered, 108 being children and young people under the age of 20.